{"id":10866,"date":"2026-07-31T13:38:41","date_gmt":"2026-07-31T11:38:41","guid":{"rendered":"https:\/\/www.ab-science.com\/?page_id=10866"},"modified":"2026-09-23T19:24:01","modified_gmt":"2026-09-23T17:24:01","slug":"masitinib-drepanocytose","status":"publish","type":"page","link":"https:\/\/ab-science.excalibra.com\/fr\/science\/masitinib-drepanocytose\/","title":{"rendered":"Masitinib dans la dr\u00e9panocytose"},"content":{"rendered":"

[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_column_text el_class=\u00a0\u00bbab-science-page-intro\u00a0\u00bb]<\/p>\n

La dr\u00e9panocytose d\u00e9signe un groupe de maladies h\u00e9r\u00e9ditaires des globules rouges. Le masitinib est d\u00e9velopp\u00e9 pour traiter les formes les plus s\u00e9v\u00e8res de la maladie, qui repr\u00e9sentent environ 65 % des cas. Les formes s\u00e9v\u00e8res de la maladie repr\u00e9sentent un d\u00e9fi majeur de sant\u00e9 publique et conduisent souvent \u00e0 un d\u00e9c\u00e8s pr\u00e9coce. Le traitement de la dr\u00e9panocytose peut \u00eatre curatif gr\u00e2ce \u00e0 la th\u00e9rapie g\u00e9nique (qui cible la mutation HbS), mais cette option reste extr\u00eamement limit\u00e9e en raison de probl\u00e8mes de s\u00e9curit\u00e9 non r\u00e9solus et de co\u00fbts tr\u00e8s \u00e9lev\u00e9s. Le traitement standard de la dr\u00e9panocytose comprend des transfusions de globules rouges et un traitement par hydroxyur\u00e9e pour g\u00e9rer les complications ; le besoin m\u00e9dical reste n\u00e9anmoins important.<\/div>\n

[\/vc_column_text]

<\/span>M\u00e9canisme d'action du masitinib dans la dr\u00e9panocytose<\/span><\/div><\/div>
<\/div>[vc_column_text]Le r\u00f4le majeur, dans la dr\u00e9panocytose, de l’inflammation m\u00e9di\u00e9e par les cellules immunitaires inn\u00e9es et favorisant la vaso-occlusion a r\u00e9cemment \u00e9t\u00e9 mis en \u00e9vidence. En particulier, nos observations cliniques et nos travaux exp\u00e9rimentaux chez la souris ont mis en \u00e9vidence l’implication des mastocytes et des basophiles dans les complications associ\u00e9es \u00e0 la dr\u00e9panocytose\u00a0:<\/p>\n
    \n
  • Le degr\u00e9 d’activation des mastocytes chez les patients atteints de dr\u00e9panocytose pourrait participer \u00e0 l’h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 de l’inflammation et des complications chroniques et aigu\u00ebs.<\/li>\n
  • Le r\u00f4le potentiel des basophiles dans la dr\u00e9panocytose n’a pas \u00e9t\u00e9 \u00e9tudi\u00e9, mais compte tenu de leur r\u00f4le dans diverses maladies et de leur capacit\u00e9 \u00e0 lib\u00e9rer de la substance P et de l’histamine, ils pourraient \u00e9galement \u00eatre des acteurs importants de la physiopathologie de la dr\u00e9panocytose.<\/li>\n<\/ul>\n

    Le masitinib est un inhibiteur de KIT, LYN et FYN, trois kinases majeures impliqu\u00e9es dans l’activation des mastocytes et des basophiles.[\/vc_column_text]

    <\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

    [vc_row][vc_column][vc_row_inner][vc_column_inner][vc_column_text el_class=\u00a0\u00bbab-science-page-intro\u00a0\u00bb] La dr\u00e9panocytose d\u00e9signe un groupe de maladies h\u00e9r\u00e9ditaires des globules rouges. Le masitinib est d\u00e9velopp\u00e9 pour traiter les formes les plus s\u00e9v\u00e8res de la maladie, qui repr\u00e9sentent environ 65 % des cas. Les formes s\u00e9v\u00e8res de la maladie repr\u00e9sentent un d\u00e9fi majeur de sant\u00e9 publique et conduisent souvent \u00e0 un d\u00e9c\u00e8s pr\u00e9coce. 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